Prevention of spontaneous diabetes in BB rats with FK 506

Effect of FK 506 on spontaneous diabetes in BB rats.

From days 30-120 after birth, 59 BB rats were treated with water (n = 20) or FK 506 in intragastric doses of 1 mg.kg-1.day-1 (n = 19) or 2 mg.kg-1.day-1 (n = 20). Diabetes developed in 75, 15, and 0% of the 3 groups, respectively. Animals protected from diabetes by FK 506 had normal intraperitoneal glucose tolerance tests, virtual absence histopathologically of autoimmune insulitis, and normal ...

FK 506 prevents spontaneous diabetes in the BB rat.

The BB rat is the experimental analogue of human juvenile diabetes mellitus. From 30 through 120 days after birth, 59 BB rats were treated with water (n = 20), or FK 506 in daily intragastric doses of 1 mg/kg (n = 19) or 2 mg/kg (n = 20). Diabetes developed in 75%, 15%, and 0% of the three groups. Animals protected from diabetes by FK 506, and killed in the nondiabetic state at 120 days had nor...

Protective effect of FK 506 against hepatic ischemia in rats.

Studiesof Repeated Administration of Fk-506 Dial Metabolism in Rats

The effect of a 14-day administration of FK-506 at 1 or 3 mgflcg ofi plasma lipids and myocardial energy and glucose metabolism in rats was investigated. FK-506 increased the level of blood glucose in rats when given daily at an oral dosage of 3 mgrkg for 14 days. T?ie plasma ]evel of total cholesterol was significantly increased by F}(-506 at either 1 or 3 mgXkg, whereas that of triglyceride w...

Notes on FK 506.